E-mail : dr.vaibhavdubey@gmail.com

Timings : Monday to Saturday 06:00 PM to 08:00 PM

Call +91 9424401688

Predictors of Antidepressant Response

Predictors of Antidepressant Response

Predictors of Antidepressant Response

 

 Predictors of Antidepressant Response

Positive Predictors

Negative Predictors

-Vegetative symptoms (anorexia, weight loss, middle and late insomnia)

-Diurnal mood variation

-Psychomotor agitation or retardation

-Autonomous and pervasive symptoms

-Acute onset

-Family history of depression

-Dose of imipramine (or equivalent dose of another heterocyclic) above 125–150 mg/day

-Blood levels of desipramine (or imipramine and desipramine) above 200 ng/ml, and nortryptiline between 50 and 150 ng/ml

-Coexistence of other significant psychiatric disturbances (particularly with hysterical or externalizing features)

-Chronic symptoms

-Psychotic features

-Hypochondriacal concerns or predominant somatic features

-Previous drug trial failure(s)

-History of sensitivity to adverse reactions